Preparation and release performance of drug loaded silica microspheres
In this paper,using an oil-in-water Pickering emulsion as template and aspirin as drug model,SiO2 drug-loaded microspheres were prepared by one-step synthesis and post-loading method.The morphology and structure of drug-loaded microspheres were characterized by Fourier transform infrared(FTIR)spectroscopy and optical microscope.The results of optical microscopy showed that the microspheres were uniform and the FTIR analysis showed that aspirin existed in the microsphere.And then the release performances of the above two kinds of drug-loaded microspheres were investigated.The results showed that the drug-loaded microspheres through one-step synthesis method showed slow drug release rate in simulated intestinal fluid and gastric fluid.
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