首页|共载黄芪甲苷-黄连素/白及多糖微球的制备与性能研究

共载黄芪甲苷-黄连素/白及多糖微球的制备与性能研究

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利用白及多糖的生物黏附性制备共载黄芪甲苷-黄连素/白及多糖微球(AS-IV-BBR/BSP-Ms),并对其性能进行评价.结果表明,采用乳化交联法制备得到共载AS-IV-BBR/BSP-Ms,微球粒径在30～40 μm,Zeta电位为-21.4 mV,且30 min内溶胀率达54.3％;红外光谱分析、X-射线衍射分析表明,黄芪甲苷和黄连素被包裹于白及多糖微球内部;DSC分析表明,在t=121 ℃时,出现尖锐吸热峰,热稳定性较好;体外抗氧化活性实验表明,该微球DPPH自由基的半数清除浓度(IC50)为8.23 mg/mL.该制备工艺稳定可行,微球性能评价达到预期目标,可为下一步药效学评价提供实验依据.
Preparation and properties study of co-delivery astragaloside Ⅳ-berberine with bletilla striata polysaccharide microspheres
co-Delivery Astragaloside Ⅳ-berberine with Bletilla striata polysaccharide Microspheres(Ms)was prepared by using the bioadhesive property of bletilla striata polysaccharide and their properties were evaluated.The results showed that co-delivery Astragaloside Ⅳ-berberine with bletilla striata polysaccharide microspheres(AS-IV-BBR/BSP-Ms)were prepared by emulsion crosslinking method,the particle size of the drug-carrying microspheres was 30～40 μm,the zeta potential was-21.4 mV,the swelling ratio could reach upwards of 54.3％in 30 min.The infrared spectroscopy and X-ray diffraction analysis showed that astragaloside Ⅳ and berberine were wrapped in the white and polysaccharide microspheres.DSC analysis showed that a sharp endothermic peak appeared at about 121 ℃ with good thermal stability.The in vitro antioxidant activity experiments showed that the DPPH radical scavenging IC50 was 8.23 mg/mL.The preparation process was stable and feasible,and the properties evaluation of microspheres reached the expected goal,which could provide experimental basis for the next pharmacodynamic evaluation.

Astragaloside ⅣBerberineBletilla striata polysaccharideMicrosphereQuality evaluation

陈程、闫梦茹、郑卓、葛鹏辉、罗国平、赵宁、薛守宇

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西安医学院药学院,陕西西安 710021

黄芪甲苷 黄连素 白及多糖 微球 质量评价

陕西省科技厅科技计划项目青年项目2022年度陕西高校青年创新团队科研计划项目陕西省科技厅自然科学研究项目陕西高校青年创新团队建设项目西安医学院科技创新团队配套西安医学院科技能力提升项目

2023-JC-QN-082222JP0752022JM-568陕教[2019]90号2021TDPT042022NLTS066

2024

化工科技
中国石油天然气股份有限公司吉林石化分公司

化工科技

CSTPCD
影响因子：0.386
ISSN：1008-0511
年,卷(期)：2024.32(3)