化工科技2024，Vol.32Issue(3) ：40-45.

多指标综合评分法结合Box-Behnken响应面法优选栀子茯苓压片糖果的提取工艺

Optimization of gardenia and poria cocos tablet candy extractionprocess by box-behnken experimental design with multi-index comprehensive scoring method

邓刚 梁可文 蒋婳影
化工科技2024，Vol.32Issue(3) ：40-45.
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  • 维普
  • 万方数据

多指标综合评分法结合Box-Behnken响应面法优选栀子茯苓压片糖果的提取工艺

Optimization of gardenia and poria cocos tablet candy extractionprocess by box-behnken experimental design with multi-index comprehensive scoring method

邓刚 1梁可文 2蒋婳影3
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作者信息

  • 1. 广西中医药大学高等职业技术学院,广西 南宁 530000
  • 2. 广西麦克健丰药业有限公司,广西 南宁 530104
  • 3. 广西中医药大学赛恩斯新医药学院,广西南宁 530222
  • 折叠

摘要

以提取液中栀子苷含量及干膏率作为考察指标,在单因素试验基础上采用直接回流提取法、多指标综合评分法结合Box-Behnken响应面法考察了乙醇浓度、提取时间和料液比3个因素对提取工艺的影响.结果表明,制剂的最佳提取工艺为乙醇浓度75％,提取时间120 min,料液比17倍,栀子苷平均含量为3.17％,平均干膏率为11.33％,综合评分平均值为98.30(n=3,RSD=0.18％).该工艺合理可行,有效成分提取率高,适合大规模生产.

Abstract

The content of geniposide in the extract and the dry paste rate were used as the investigation indexes.On the basis of single factor experiment,the direct reflux extraction method was used,and the multi-index comprehensive scoring method combined with Box-Behnken response surface method was used to investigate the effects of ethanol concentration,extraction time and solvent doubling on the extraction process.The results showed that the optimal extraction process was 75％ethanol,120 min extraction time and 17 times solvent doubling.The process is reasonable and feasible,and the extraction rate of active components is high.It is suitable for large-scale production and provides a scientific basis for industrial production.

关键词

栀子茯苓压片糖果/多指标综合评分法/Box-Behnken响应面法/提取工艺

Key words

The tablet candy of gardenia and poria cocos/Multi-index comprehensive scoring method/Box-Behnken experimental design/Extraction technology

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基金项目

广西高校中青年教师(科研)基础能力提升项目(2020KY59013)

出版年

2024
化工科技
中国石油天然气股份有限公司吉林石化分公司

化工科技

CSTPCD
影响因子：0.386
ISSN：1008-0511
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