Optimization of preparation process of benzothiazole using Box-Benhnken response surface methodology and its antimicrobial properties
Benzothiazole is a widely used fungicide,and the purity of the final product is closely related to the process conditions.In this study,based on single-factor experiments,a response surface optimization experiment was designed according to the principles of Box-Benhnken central composite design.The optimized results determined the best experimental process as follows:reaction temperature of 71.69 ℃,reaction time of 6.63 hours,and the ratio of CH2ClBr to MBT addition as 10.59.The purity of TCMTB obtained by verification experiment was 71.08％,which was basically consistent with the model experiment results,and the prepared TCMTB exhibits good antibacterial properties.
万方数据
维普
