In order to explore the factors that affect the stability of furosemide oral solution and predict its validity,an accelerated testing method was used.The methods were used to study the effects of temperature,light and storage time on the stability of furosemide oral solution,and calculate the degradation rate constant(K25℃)and validity period of furosemide oral solution at 25 ℃.The results indicated that the furosemide oral solution was unstable in case of light,temperature,and gradually decomposed with time.The degradation reaction is one grade,and the validity is 305 days at 25 ℃.It was recommended that the furosemide oral solution should be filled in a brown glass bottle and stored in a cool,dark place.
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