Taking the Disc centrifuge drum as the research object,the structural dynamic reliability model with considering the randomness of time-varying load and structural parameters is established,and the reliability and failure rate of drum body are obtained.Firstly,the analytical dynamic model considering fluid-structure interaction is established by using Lagrange equations;Then,imposed the fluid-structure coupling load in ANSYS simulation software,and by using random sampling,we obtain the statistical characteristics of the drum body stress distribution;Finally,the evaluation index of structural dynamic reliability is given by using stochastic process and stress-strength interference theory.The results show that:under normal working conditions,the maximum stress concentration area of the Disc centrifuge drum occurs in the sediment area,and its equivalent force presents a time-varying normal distribution.After continuous working for 2 000 hours,the probability of drum strength meeting the requirements is less than 80%,and the service life conforms to the characteristics of early failure in the"bathtub"curve,which lays a foundation for the dynamic optimization design of high-speed Disc centrifuge.