The determination of the optimal replacement cycle for heat exchanger tube bundles based on API 581 addresses the issues of easy leakage,unclear replacement cycle,and insufficient scientific and rigorous estimation methods in heat exchanger tube bundles of petrochemical enterprises.Based on the American Petroleum Institute standard API 581-2016"Risk Based Inspection Method",The economic cost analysis method was used to conduct a decision analysis on the inspection or replacement of the heat exchange tube bundle of a medium pressure decomposer in a certain refining and chemical enterprise,and the optimal replacement cycle of the tube bundle was calculated.The results indicate that the return rate of a company will be related to the decision-making of inspection or replacement,affecting the determination of the earliest inspection or replacement date;The optimal replacement cycle of the tube bundle based on total cost optimization calculation is 9.5 years;The greater the difference between the risk cost of unplanned downtime and the cost of replacing the tube bundle for planned downtime,the greater the importance of managing the integrity of the heat exchanger according to the optimal replacement cycle of the tube bundle.