Fracturing manifold is the blood of the whole fracturing system.Under the conditions of high load and long period continuous operation,fracturing manifold is prone to leakage,burst and seal failure.The failure of manifold elements will seriously affect the progress of oil production,restrict the efficiency and economic benefit of oil and gas exploitation,and even threaten the personal safety of site construction personnel.In this paper,the three-dimensional simulation model of movable elbow of fracturing manifold under different installation angles is established,the erosion wear law of fracturing manifold under different installation angles,mass flow rate and particle size is studied,and the influence of structural parameters of fracturing manifold on erosion is optimized by multiple factors.The results show that when the inlet and outlet Angle θ is 120°,the erosion wear degree of fracturing manifold is the lowest.The larger the particle mass flow rate and particle size are,the more serious the erosion wear of fracturing manifold is.According to regression analysis by CCD response surface method,the weight of factors affecting erosion wear rate is manifold diameter>elbow angle>bend diameter ratio.