Preparation and Performance Study of Sodium Alginate Loaded Oral Instant Film
In response to the current issues of sudden drug release,low drug utilization,and sustained drug release,sodium alginate(SA)and hydroxypropyl methyl cellulose(HPMC)were used as film forming agents,and sodium alginate oral instant film was pre-pared by casting film forming method.The chemical structure,transparency,and water solubility of the films were analyzed,and the optimal film-forming ratio of SA and HPMC was obtained,and the preparation of sodium alginate loaded oral instant film with benz-damine hydrochloride(BH).The results showed that the optimal film-forming agent ratio was w(SA):w(HPMC)=1:2.In addition,when the BH loading capacity was 30％,the mechanical properties of sodium alginate loaded oral instant film were the best.When the loading capacity is 40％,its encapsulation efficiency and drug loading efficiency were the best,and the economic cost was better.
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