To address the issues of cumbersome synthesis steps and low yield in the synthesis of indapamide,this article used 2-methylindoline and p-chlorobenzenesulfonic acid as the main raw materials,and studied the effects of reaction temperature,reaction time,acid scavenger,and solvent on the yield of indapamide through Zn/AcOH catalytic hydrogenation、nucleophilic condensation reaction,salt formation and ion exchange,and purification methods.The results showed that when the reaction time was 24 h,the reaction temperature was-5～0℃,and triethylamine was used as the acid scavenger during the synthesis of crude indapamide,the yield could reach 88.2%.In the purification stage of crude indapamide,using a mixed solvent of volume ratio of isopropyl alcohol to water of 3:2,indapamide products with a yield of 92.8%and a purity of 99.5%could be obtained.This method has the advantages of simple steps,mild conditions and lower cost,and is suitable for industrial production.
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