Examples of Enantiomer Resolution by Co-crystallization Technique
Chiral resolution of racemate is the most efficient and convenient way to prepare single enantiomers,and crystal resolution is the most important and widely used technology to achieve chiral single enantiomer separation.The research progress of enantioselective cocrystallization resolution of lamivudine,baclofen,eracetam and ibuprofen is reviewed.This selectivity is caused by the highly oriented nature of hydrogen bonds in cocrystal,and is a useful supplement for salt crystallization resolution.The technology is still in the development stage,and there are still many challenges in designing chiral resolution processes for cocrystallization.
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