Improvement of Synthetic Process of 21-Hydrocortisone Chloride
Considering the issues of high cost and high toxicity of reagents in the current process for synthesizing 21-chlorohydrocortisone,9-hydroxy-androstenedione was used as raw material to prepare 21-hydrocortisone chloride by four steps of cyanidation,elimination,silotheration and rearrangement.The reaction conditions of each step were investigated and the optimal process route was obtained.The structure of the product was characterized by NMR and MS data.The experimental results show that the method has the advantages of cheap raw materials,low production cost and less discharge of three wastes.The total yield can reach 66.9%,which is suitable for industrial amplification.
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