N-heterocyclic molecules are an important class of pharmaceutical block molecules,often used as intermediates for the synthesis of peptide pharmaceutical molecules.This article reports a new synthesis method for N-heterocyclic molecule 1-pyridyl-3-piperidin-4-carboxylic acid.3-Bromopyridine,4-piperidine ethyl formate,potassium carbonate,and N-methylpyrrolidone were added to the high-pressure reactor in sequence.The solution was kepted at 180 oC and 0.5 MPa for 72 hours,which was monitored by LC-MS.After the reaction finished,cooled the reaction system to room temperature,the filter cake was beaten with methanol and filtered again.The filtrate was concentrated and then recrystallized with methanol to obtain a yellow powder with a yield of 46%.This synthesis method,under alkaline high-pressure conditions,yields the target compound through one-pot reaction,greatly reducing industrial costs.The one-pot reaction is simple and has a high yield,and has industrial production prospects.
维普
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