In this paper,a three-dimensional model of a double raft pile foundation of 200,000 m3 LNG storage tank was established based on ANSYS software for vibration isolation design and analysis,and a method to solve the vibration isolation coefficient based on the simplified particle model was proposed.The results show that this method not only guarantees the accuracy but also greatly improves the calculation efficiency,providing theoretical reference and effective data for determining the vibration isolation coefficient.In addition,a simplified particle point model of the 200,000 m3 LNG storage tank's single raft high pile cap foundation was established for vibration isolation design analysis.By comparison,the double raft foundation is better than the single raft foundation in reducing the seismic response,but attention should be paid to the amplification effect of the seismic response of the external tank and the dome under the condition of OBE full tank and SSE full tank.