Moxifloxacin hydrochloride is a fourth-generation fluoroquinolone drug with a wide range of clinical applications,good efficacy,so as a huge market demand.Therefore,study in the synthesis process of moxifloxacin hydrochloride to achieve cost reduction and production increase has strong practical significance for both the pharmaceutical industry and patients.this article reviews the progress and optimization of the synthesis process of moxifloxacin hydrochloride in recent years,discusses the advantages and disadvantages of several main methods,and attempts to summarize a feasible and exploratory experimental process route.