化工设计通讯2024,Vol.50Issue(7) :166-169.

第四代喹诺酮类抗菌药盐酸莫西沙星合成工艺进展与优化

Synthesis Process Progress and Optimization of Moxifloxacin Hydrochloride Which is the Fourth Generation of Quinolone Antibacterial Drug

杨子琪
化工设计通讯2024,Vol.50Issue(7) :166-169.

第四代喹诺酮类抗菌药盐酸莫西沙星合成工艺进展与优化

Synthesis Process Progress and Optimization of Moxifloxacin Hydrochloride Which is the Fourth Generation of Quinolone Antibacterial Drug

杨子琪1
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作者信息

  • 1. 杨凌职业技术学院,陕西杨凌 712100
  • 折叠

摘要

盐酸莫西沙星是第四代氟喹诺酮类药物,临床应用领域广、效果良好,市场需求巨大,因此,研究盐酸莫西沙星合成工艺实现降本增产,对于制药行业和患者双方都有着很强的现实意义.通过对近年来盐酸莫西沙星合成工艺的进展与优化情况进行综述,探讨几种主要方法的优劣,并尝试汇总出一条较为可行、具有探索实验意义的工艺路线.

Abstract

Moxifloxacin hydrochloride is a fourth-generation fluoroquinolone drug with a wide range of clinical applications,good efficacy,so as a huge market demand.Therefore,study in the synthesis process of moxifloxacin hydrochloride to achieve cost reduction and production increase has strong practical significance for both the pharmaceutical industry and patients.this article reviews the progress and optimization of the synthesis process of moxifloxacin hydrochloride in recent years,discusses the advantages and disadvantages of several main methods,and attempts to summarize a feasible and exploratory experimental process route.

关键词

盐酸莫西沙星/盐酸莫西沙星侧链/(S,S)-2,8-二氮杂双环[4.3.0]壬烷/喹啉羧酸/盐酸莫西沙星合成路线

Key words

moxifloxacin hydrochloride/moxifloxacin hydrochloride side chain/(S,S)-2,8-diazabicyclic[4.3.0]nonane/quinoline carboxylic acid/synthetic route of moxifloxacin hydrochloride

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基金项目

杨凌职业技术学院院内基金项目(ZK20-75)

出版年

2024
化工设计通讯
湖南化工医药设计院

化工设计通讯

影响因子:0.126
ISSN:1003-6490
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