Application of Nitrogen Protection in Air Flow Drying of API
In recent years,dust explosion accidents have occurred frequently,causing multiple injuries and even deaths.Factories and equipment have been damaged,seriously damaging people's lives and property safety.The drying process in the production of active pharmaceutical ingredients inevitably involves combustible dust and dust explosion environments,which belong to accident prone positions.Pharmaceutical companies have adopted various methods to prevent the occurrence of dust explosions.After years of design theory combined with practical testing in pharmaceutical factories,the author explores the application of nitrogen protection in the airflow drying of raw materials.Nitrogen protection is the use of the chemical properties of nitrogen to create an inert environment during the drying process of raw materials,isolating the contact between combustible dust and external air,thereby reducing the possibility of accidents.This article first introduces the principle of nitrogen protection,including concepts such as the limit oxygen concentration of combustible materials and inerting;Next,the practical application of nitrogen protection in the airflow drying of active pharmaceutical ingredient aminopyrine was discussed,covering the drying process flow,control measures adopted,and calculation of nitrogen dosage.The device has been operating safely since its completion in 2015,and no safety accidents have occurred.
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