Pyrimidine compounds are an important class of pharmaceutical building blocks,often used as raw materials for the synthesis of drugs,pesticides,and other molecules.This study describes a synthesis method for the pyrimidine compound 2-methoxy-5-cyanopyrimidine.The method uses Copper(I)cyanide as the Cyanide reagent and 2-methoxy-5-bromopyrimidine as the starting material to successfully prepared 2-methoxy-5-cyanopyrimidine.The reaction conditions were optimized during the synthesis process,this method significantly improved the yield and purity of the product,reduced impurity content,and lowered production costs,which gives the synthesis method good prospects for industrial application.