一种提高盐酸莫西沙星异构体分离度的方法

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中文摘要：基于Agilent Poroshell EC-C18色谱柱(4。6 mm×100 mm，2。7 μm)，作者研究了提高盐酸莫西沙星及其对映异构体分离度的方法。结果表明，当流动相A为含有醋酸铵、硫酸铜和L-异亮氨酸的水溶液，且醋酸铵浓度为50 mmol·L-1，硫酸铜的浓度为5 mmol·L-1，L-异亮氨酸的浓度为10 mmol·L-1，流动相B为甲醇，流动相A与流动相B体积之比为70∶30，流速为1。0mL·min-1，进样量为10 µL，柱温为40 ℃，检测波长为293 nm时，盐酸莫西沙星对映异构体分离度达到6。4。该方法不使用手性色谱柱，相比现有技术，可以更好地分离盐酸莫西沙星及其对映异构体。

外文标题：A Method for Improving the Separation Degree of Isomers of Moxifloxacin Hydrochloride

外文摘要：Based on the Agilent Poroshell EC-C18 chromatography column(4.6 mm× 100 mm,2.7 µm),the authors studied a method to improve the separation of moxifloxacin hydrochloride and its enantiomers.The results showed that when mobile phase A was an aqueous solution containing ammonium acetate,copper sulfate,and L-isoleucine,with ammonium acetate concentration of 50 mmol·L-1,copper sulfate concentration of 5 mmol·L-1,L-isoleucine concentration of 10 mmol·L-1,mobile phase B was methanol,the volume ratio of mobile phase A to mobile phase B was 70∶30,the flow rate was 1.0 mL·min-1,the injection amount was 10 µL,the column temperature was 40 ℃,and the detection wavelength was 293 nm,the resolution of moxifloxacin hydrochloride isomers reached 6.4.This method did not use chiral chromatography columns,and had a better separation moxifloxacin hydrochloride and its isomers compared to existing technologies.

外文关键词：

moxifloxacinenantiomerchiral isomersammonium acetate

作者：

赵琳、夏瑛、龚云霞、朱兰芳

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作者单位：

浙江医药股份有限公司新昌制药厂,新昌 312500

关键词：

莫西沙星对映异构体手性异构体醋酸铵

出版年：

2024

DOI：