Application and prospect of organoids-on-chip in the study of nano-drug delivery systems
Organoids are self-assembling three-dimensional multicellular structures derived from human stem cells,organ-specific progenitor cells or isolated tumor tissues,which could reproduce the key structural features and physiological functions of organs in vitro.As an in vitro culture platform for organoids,microfluidic chips provide opportunities to study the behavior of cells in heterogeneous populations and microenvironments.Therefore,they have become a powerful tool to assist human organ development research,disease modeling,and drug screening.Nanomaterials,as an advanced carrier for drug delivery,can significantly improve the therapeutic effects of drugs and have become the focus of new drug development.Organoids-on-chip not only provide a reliable platform for evaluating the safety and efficacy of nano-drug delivery systems,but also help the design of nanocarriers and personalized treatment.In this review,we give an update on the limitations of traditional two-dimensional cell models and animal models in nano-drug delivery systems evaluation,with an emphasis on the advantages of in vitro platforms by organoids-on-chip.It also summarized the recent application and development of organoids technology and future directions in nano-drug delivery systems.
国家科技期刊平台
NSTL
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