摘要
作为一种生物分子构建单元,肽具有生物相容性、可降解性、多功能性和序列可调性等特性.利用肽分子的非共价化学,可以实现具有多尺度结构的新型材料的可控构建,为开发生态友好、生物可降解和生物再利用的绿色生物可循环材料提供了新策略.然而,如何利用肽非共价化学策略进行单分子设计,并实现绿色生物可循环材料的可控构建和功能化应用,面临着重要挑战.本文从肽分子间的弱相互作用力协同角度,介绍肽非共价化学的策略,并详细阐述实现绿色生物可循环肽材料可控构建的单分子设计策略.最后,对基于非共价化学的绿色生物可循环肽材料在仿生光合成和光催化、药物递送和疾病诊疗以及可加工材料等领域的应用进行综述.
Abstract
Peptides,as a class of biomolecular building units,have biocompatibility,biodegradability,versatility,and sequence diversity,and can form novel materials with multi-scale structures through noncovalent chemistry.The emergence of these peptide based noncovalent chemical materials provides a method for developing eco-friendly,biodegradable and biorecyclable green biorecyclable materials.However,achieving controllable construction and functionalization of materials from single molecule design through noncovalent chemistry of peptides remains a challenge.Therefore,the article first introduced what noncovalent chemistry of peptides is,mainly describing weak intermolecular interactions.Then,it summarized how to achieve controllable construction of peptide materials from single molecule design,mainly introducing three design strategies.Finally,the applications of peptide-based materials,including biomimetic photosynthesis and photocatalysis,drug delivery and disease diagnosis and therapy,as well as processable materials,were reviewed.
国家科技期刊平台
NSTL
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