Synthetic biology of yeasts drives green biomanufacturing of succinic acid
Succinic acid is an important C4 platform chemical,and its industrial biomanufacturing route has significant advantages,which is a research hotspot.The microorganisms for succinic acid biosynthesis mainly include bacteria and yeasts.Compared with bacteria,although the product yield of yeasts is lower,the yeasts generally have high acid tolerance,therefore,they can synthesize succinic acid under low pH conditions,thus avoiding adding additional neutralization agent to maintain the neutral pH conditions,therefore,the downstream process for yeast-based succinic acid purification is simpler and costs lower.This article reviews the research progress in the use of yeast microorganisms to synthesize succinic acid in recent years,focusing on the synthetic biology transformation strategies of yeast production strains represented by Saccharomyces cerevisiae,Yarrowia lipolytica,and Issatchenkia orientalis.Finally,the future directions for green biomanufacturing of succinic acid by constructing yeast cell factories are proposed.
国家科技期刊平台
NSTL
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