微流控可控制备液滴、颗粒和胶囊及其应用
Controlled preparation of droplets,particles and capsules by microfluidics and their applications
吉笑盈 1郑园 2李晓鹏 1杨振 1张维 3邱诗蕊 3张倩颖 1罗沧海 2孙东鹏 2陈东 2李东亮1
作者信息
- 1. 四川中烟工业有限责任公司烟草行业雪茄发酵工艺重点实验室,四川 成都 610100;四川中烟工业有限责任公司厅市共建国产雪茄烟叶工业高效利用重点实验室,四川 成都 610100
- 2. 浙江大学能源工程学院,浙江 杭州 310029
- 3. 四川中烟工业有限责任公司长城雪茄厂,四川 什邡 618400
- 折叠
摘要
微流控技术在可控制备液滴、颗粒和胶囊方面具有独特优势,能够精确控制液滴、颗粒和胶囊的粒径大小、尺寸分布、形貌结构和材料组成,在生物医药、食品、护肤品等领域具有广泛应用.详细总结了微流控技术可控制备液滴、颗粒和胶囊所用的器件设计、工艺策略及其相关应用.此外,还重点介绍了多相流数值模拟在液滴、颗粒和胶囊制备过程和优化实验参数中的应用,以及微流控器件实现液滴、颗粒和胶囊量产的平行放大策略.将为液滴、颗粒和胶囊的制备和应用提供重要指导.
Abstract
Microfluidics has unique advantages in the controlled preparation of droplets,particles and capsules.Microfluidics could precisely control the size,distribution,structure and composition of droplets,particles and capsules,which are widely used in the field of biomedicine,food and cosmetics.This review comprehensively summarizes the device design,preparation strategy and industrial application for the controlled preparation of droplets,particles and capsules by microfluidics.In addition,the application of multiphase flow numerical simulation of the preparation process of droplets,particles and capsules and the optimization of experimental parameters are also highlighted,as well as the parallel scale-up strategy of microfluidic devices to achieve mass production of droplets,particles and capsules.This review will provide an important guide for the preparation and application of droplets,particles and capsules.
关键词
微流控/液滴/颗粒/胶囊/数值模拟/平行放大/微通道Key words
microfluidics/droplet/particle/capsule/numerical simulation/parallel scale-up/microchannel引用本文复制引用
基金项目
地市级科研项目(20202303BA530)
国家重点研发计划(2021YFC3001100)
出版年
2024
国家科技期刊平台
NSTL
万方数据