Hydrogel-based drug releasing system with external electricity stimulation for wound dressing
Hydrogel is a polymer material with a three-dimensional network structure and can be used as an ideal new wound dressing.However,the releasing rate of hydrogel wound dressing is slow under natural conditions.To promote wound healing,the hydrogel is prepared by using carboxymethyl chitosan and sodium alginate as matrix,and polypyrrole as the conductive agent.The ciprofloxacin hydrochloride is added into the hydrogel as the antibacterial drug.The drug releasing device driven by the electrostimulation is constructed.The impacts of polypyrrole content on the swelling property,mechanical property and electrical conductivity,and the releasing property of ciprofloxacin hydrochloride under electrical stimulation are studied.When the ratio of polypyrrole to the matrix is 0.4,the hydrogel shows the optimized comprehensive performance in physicochemical property and mechanical property,and is more suitable for wound dressing.The electrical stimulation can effectively accelerate the releasing rate of drugs interior the hydrogel,and benefit the treatment of wounds.
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