Application of automation and artificial intelligence in flow chemistry
Flow chemistry,as an important frontier technology in chemical synthesis,has the characteristics of high efficiency,safety,controllability,and environmental protection.It is widely used in drug synthesis,fine chemicals,and materials science.Recent advances in automation and artificial intelligence(AI)have enabled flow chemistry to achieve full-process automation and intelligence.Automated systems integrate equipment and control systems to monitor and regulate reaction conditions in real-time,minimizing human error and enhancing stability and reproducibility.AI algorithms allow these systems to handle large data volumes,navigate high-dimensional chemical space,shorten experimental cycles,and improve efficiency and yield.This paper summarizes the development of intelligent flow chemistry systems,discusses the construction and application of the automated systems,and explores AI-based advancements,including machine learning algorithms and large language models.Case studies highlight the significant potential and application prospects of intelligent flow chemistry systems in chemical synthesis.