Synthesis of amphiphilic polyphosphoester-PTX prodrug and its potential in reduction-responsive drug release
The block copolymer mPEG44-b-PBenEP44 was prepared by the ring-opening polymerization of BenEP with monomethoxy polyethylene glycol(mPEG)as macroinitiator.A reduction-responsive polyphosphate-based paclitaxel prodrug mPEG44-b-(PBenEP34-g-SS-PTX3)(PEBSP)was prepared by introducing the disulfide bond and paclitaxel into the pendant groups of PBenEP block,and the drug loading content(DLC)is 14.57％.The self-assembly behavior of PEBSP was studied by transmission electron microscopy(TEM),dynamic light scattering(DLS)and fluorescent analyses.The results show that PEBSP can form spherical particles with an average size of 71 nm in aqueous solution,and its critical micelle concentration is determined to be 60 mg·L-1.PEBSP spherical nanoparticles can exist stably under normal conditions,and in a reducing medium(10 mmol·L-1 glutathione),the disulfide bond breaks and the drug paclitaxel is released in a controllable and continuous manner.
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