Preparation and application of metal oxide-based composite nanomaterials
First,small bimetallic oxide nanoparticles(CuFe2O4)were prepared from iron acetylacetonate[Fe(C5H7O2)3,98％],copper acetylacetonate[Cu(C5H7O2)2,97％],and triethylene glycol(TEG).The small bimetallic oxide nanoparticles(CuFe2O4)were loaded on magnesium peroxide(MgO2)nanosheets by electrostatic adsorption to form metal oxide-based composite nanomaterials(CuFe2O4@MgO2).The composite nanomaterials could produce a large number of highly toxic hydroxyl radicals(·OH)under acidic conditions in tumors,which had a large damaging effect on tumor cells.Transmission electron microscopy(TEM),XPS spectroscopy,and zeta potential were used to characterize the composite nanomaterials.The results showed that CuFe2O4 nanoparticles were distributed on the surface of magnesium peroxide(MgO2)nanosheets,and zeta potential measurements confirmed the successful preparation of this composite nanomaterial.In vitro cellular experiments demonstrated that the composite nanomaterials possessed anti-tumor therapeutic effects.
metal oxideselectrostatic adsorptionreactive oxygen speciestumor therapy
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维普
