Effect of Low Molecular Weight Heparin Calcium Combined with Rivar-oxaban in the Treatment of Lung Cancer Patients with Acute Pulmonary Embolism
Objective To investigate the effect of low molecular weight heparin calcium combined with rivaroxaban in the treatment of lung cancer patients with acute pulmonary embolism.Methods 98 patients with lung cancer compli-cated with acute pulmonary embolism admitted to Sanming First Hospital Affiliated to Fujian Medical University from May 2020 to August 2022 were conveniently selected and divided into two groups according to random number table method,with 49 cases/group.After admission,patients in both groups were given conventional treatment such as pain relief,oxygen inhalation,pulmonary vasodilation,anti-inflammatory,etc.The control group was given low molecular weight heparin calcium combined with warfarin sodium tablets on the basis of conventional treatment.The observation group was given low molecular weight heparin calcium combined with rivaroxaban tablets on the basis of conventional treatment.The clinical efficacy,arterial blood gas analysis index,coagulation function and incidence of adverse reac-tions were compared between the two groups.Results The total clinical effective rate of 93.88%in the observation group was significantly higher than 77.55%in the control group,the difference was statistically significant(χ2=5.333,P<0.05).After treatment,arterial partial oxygen pressure(PaO2)(10.01±0.76)kPa and blood oxygen saturation(SaO2)(97.65±1.61)%were higher than those of control group,and the partial pressure of carbon dioxide(PaCO2)(5.48±0.42)kPa was lower than that of control group,the differences were statistically significant(t=7.588,5.540,8.178,all P<0.05).After treatment,fibrinogen(FIB)and serum D-dimer(D-D)in the observation group were lower than those in the control group,thrombin time(PT)and activated partial thromboplastin time(APTT)were higher than those in control group,the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the ob-servation group was 4.08%lower than that in the control group 20.14%,and the difference was statistically significant(χ2=6.078,P<0.05).Conclusion Low molecular weight heparin calcium combined with rivaroxaban has a significant clinical effect in patients with lung cancer complicated with acute pulmonary embolism,which can effectively improve blood gas molecular indexes and coagulation function of patients with good safety.
Lung cancerAcute pulmonary embolismLow molecular weight heparin calciumRivaroxabanBlood gas molecular indexCoagulation function
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