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扁桃体烙治疗效探讨及相关不良事件分析和对策

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目的 探讨中医烙法治疗慢性扁桃体炎的疗效,分析相关不良事件并探讨应对措施,以进一步提高其安全性.方法 随机选取2018年1月—2022年12月广州中医药大学附属中山中医院耳鼻喉科门诊收治的160例慢性扁桃体炎患者为研究对象,按随机数表法随机分为两组,治疗组105例进行扁桃体烙治,对照组55例以自拟化痰散结祛瘀利咽汤口服2周.观察治疗前后扁桃体肿大程度、临床症状积分、体征积分、扁桃体急性炎症平均每月发作次数的变化.统计两组最终接受扁桃体切除手术人数.观察并记录不良事件.结果 治疗组经中医烙治后,痊显率88.57%,总有效率98.10%;对照组经中药口服2周后,痊显率45.45%,总有效率76.36%.两组临床疗效比较,差异有统计学意义(χ2=41.711,P<0.05).治疗后,治疗组症状、体征总积分较治疗前降低且低于对照组,差异有统计学意义(P均<0.001).治疗后治疗组扁桃体急性炎症平均每月发作次数较治疗前显著减少且少于对照组,差异有统计学意义(P均<0.001).治疗组最终有1例接受扁桃体切除术;对照组最终有6例接受扁桃体切除术,两组比较,差异有统计学意义(P<0.05).治疗组出现不良反应较对照组高,差异有统计学意义(χ2=4.995,P<0.05).结论 中医烙治法治疗慢性扁桃体炎疗效显著,不断积累经验,对扁桃体烙治相关不良事件足够重视并采取积极应对措施,可进一步提高治疗安全性.
Discussion on the Efficacy of Tonsil Branding Treatment and Analysis and Countermeasures of Related Adverse Events
Objective To explore the efficacy of Chinese medicine branding in the treatment of chronic tonsillitis,to analyze the related adverse events and to discuss the countermeasures in order to further improve its safety.Methods From January 2018 to December 2022,160 patients with chronic tonsillitis admitted to the Department of Otorhinolar-yngology of Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medi-cine were randomly selected as the research object and randomLy divided into two groups according to the random number table method.105 patients in the treatment group were treated with tonsillitis cauterization,and 55 patients in the control group were treated with self-made Huatan Sanjie Quyu Liyan Decoction for 2 weeks.The degree of tonsil enlargement,clinical symptom score,sign score and the average number of tonsillar acute inflammation attacks per month were observed before and after treatment.The number of patients who finally received tonsillectomy in the two groups was counted.Adverse events were observed and recorded.Results In the treatment group,the cure rate was 88.57%,and the total effective rate was 98.10%.In the control group,after 2 weeks of oral administration of tradi-tional Chinese medicine,the recovery rate was 45.45%and the total effective rate was 76.36%.There was statistically significant difference in clinical efficacy between the two groups(χ2=41.711,P<0.05).After treatment,the total scores of symptoms and signs in the treatment group were lower than those before treatment and those in the control group,and the differences were statistically significant(all P<0.001).After treatment,the average number of tonsillar acute inflammation attacks per month in the treatment group was significantly lower than that before treatment and less than that in the control group,and the difference was statistically significant(both P<0.001).One patient in the treatment group finally received tonsillectomy.In the control group,6 cases received tonsillectomy,and the difference between the two groups was statistically significant(P<0.05).The incidence of adverse reactions in the treatment group was higher than that in the control group,the difference was statistically significant(χ2=4.995,P<0.05).Conclusion The efficacy of Chinese medicine branding treatment for chronic tonsillitis is remarkable.Continuous accumulation of ex-perience,sufficient attention to the adverse events related to tonsil branding and active countermeasures can further improve the safety of treatment.

Chinese medicine brandingTonsillitisTherapeutic effectAdverse events

徐庆文、李少华、罗齐平、林葆睿、粱华娣

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广州中医药大学附属中山中医院耳鼻咽喉科,广东中山 528400

中医烙治 扁桃体炎 疗效 不良事件

中山市卫生健康局医学科研项目

2022J014

2024

中外医疗
卫生部医院管理研究所 二十一世纪联合创新医药科学研究院

中外医疗

影响因子:0.909
ISSN:1674-0742
年,卷(期):2024.43(1)
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