Objective To observe and explore the effect of caudal lateral approach combined with intermediate flap clearance in laparoscopic radical surgery for right colon cancer.Methods 108 patients of laparoscopic radical surgery for right colon cancer in Nantong Second People's Hospital(Kangfu Hospital Affiliated to Nantong University)from January 2020 to October 2022 were selected,and they were divided into the observation group(n=54,with caudal ap-proach combined with intermediate flap clearance)and the control group(n=54,with intermediate approach)according to the method of random number table.The two groups were compared in terms of operation-related indexes,postop-erative recovery time,postoperative complication rate,and follow-up outcomes over a period of 12 months.Results In-traoperative operation time,perioperative blood loss,and the number of lymph node dissection in the observation group were better than those in the control group,the differences were statistically significant(all P<0.05).The time of the first postoperative fluid intake,the time of the first anal defecation,the time of the first time to get out of bed,and the length of hospitalization in both group,the difference was not statistically significant(all P>0.05).The postopera-tive complications between two groups,the difference was not statistically significant(P>0.05).There was no statisti-cally significant difference in the postoperative period of 12 months dynamic follow-up,tumor-free survival rate,over-all survival rate between the two groups(all P>0.05).Conclusion The prognostic effect,safety,and quality of postop-erative recovery of the caudal approach combined with intermediate flap clearance in laparoscopic radical surgery for right colon cancer are comparable to that of the conventional intermediate approach,but comparatively speaking,there are advantages of application such as shorter time-consuming,convenient operation,more quantity of lymph node dis-section,and less bleeding.