Effect of Pudilan Xiaoyan Oral Liquid Combined with Oseltamivir on the Disappearance of Clinical Symptoms and Inflammation in Children with Acute Upper Respiratory Tract Infection
Objective To investigate the effects of Pudilan Xiaoyan oral liquid combined with oseltamivir on the disap-pearance of clinical symptoms and inflammation in children with acute upper respiratory tract infection(URTI).Meth-ods A total of 360 children with URTI treated in Xintai People's Hospital from March 2019 to March 2022 were ran-domly selected and divided into control group and observation group according to random number table method.Con-trol group one hundred and eighty cases were treated with oseltamivir,observation group one hundred and eighty cases were treated with Pudilan Xiaoyan oral liquid combined with oseltamivir.After 2 consecutive courses of treatment,the clinical efficacy,disappearance of clinical symptoms,inflammatory response indexes and adverse reactions were com-pared between the two groups.Results The total effective rate(98.33%)in the observation group was significantly higher than that(92.22%)in the control group,the difference was statistically significant(χ2=7.470,P<0.05),and the disappearance time of symptoms in the observation group was significantly shorter than that in the control group,the difference was statistically significant(P<0.05).The serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and high sensitive c-reactive protein(HS-CRP)in the tumor necrosis factor group were significantly lower than those in the control group,the differences were statistically significant(all P<0.05).There was no statistically signifi-cant difference in incidence adverse reactions between groups(P>0.05).Conclusion Pudilan Xiaoyan oral liquid com-bined with oseltamivir in the treatment of URTI can improve the curative effect,accelerate the regression of clinical symptoms,reduce the inflammatory response,and have high safety.
万方数据
维普
