Effect of Sacubactril Valsartan on Chronic Heart Failure with Hyperten-sion and Its Effects on Cardiac Function
Objective To treat patients with chronic heart failure and hypertension with the drug sacubactril valsartan,and to analyze the efficacy and effect of this drug on cardiac function.Methods A total of 150 patients with chronic heart failure and hypertension treated by Zoucheng People's Hospital from January 2021 to December 2022 were ran-domly selected and divided into two groups by double-blind method,with 75 patients in each group.The control group was treated with conventional therapy,and the observation group was treated with conventional therapy com-bined with the drug sacubactril valsartan.The clinical therapeutic effect,incidence of adverse reactions,renal function indexes and cardiac function indexes were compared between the two groups.Results After treatment,the incidence of adverse reactions in observation group was 9.33%lower than that in control group 21.33%,the difference was statisti-cally significant(χ2=4.160,P<0.05).After treatment,the levels of serum creatinine,urea nitrogen and brain natri-uretic peptide in the observation group were lower than those in the control group,the differences were statistically sig-nificant(all P<0.05).After treatment,left ventricular ejection fraction in observation group was higher than control group,and left ventricular end-diastolic diameter and left ventricular end-systolic diameter were lower than control group,the differences were statistically significant(all P<0.05).Conclusion In the treatment of chronic heart failure patients with hypertension,the use of the drug sacubactril valsartan can significantly improve the level of cardiac func-tion and renal function related indicators of patients,and the incidence of adverse reactions was low.
Sacubactril valsartanChronic heart failureHigh blood pressureClinical effectCardiac function
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维普
