Analysis of the Clinical Effect of Sodium Hyaluronate Injection + Cele-coxib on Patients with Knee Osteoarthritis and the Influence of VAS Score
Objective To explore the clinical effect of sodium hyaluronate injection + celecoxib on patients with knee osteoarthritis.Methods 90 patients with knee osteoarthritis admitted to Zhenjiang 359 Hospital from January 2022 to August 2023 were randomly selected as research subjects and divided into control group and study group according to the random number table method,with 45 cases each.The control group was treated with sodium hyaluronate injec-tion,and the study group was treated with sodium hyaluronate injection + celecoxib,both group continued for 10 weeks.The total effective rate and the serum inflammatory factor indexes,pain scores,knee function scores,and qual-ity of life scores were compared between the two groups before and after treatment.Results Regarding the total effec-tive rate was 97.78%in the study group,which was higher than 82.22%in the control group,the difference was statis-tically significant(χ2=6.049,P<0.05).After treatment,serum C-reactive protein and interleukin-6 levels in the study group were lower than in the control group,the differences were statistically significant(both P<0.05).Pain scores in the study group were lower than in the control group,the difference was statistically significant(P<0.05).Knee func-tion scores and four dimensions of quality of life scores in the study group were higher than in the control group,the differences were statistically significant(all P<0.05).Conclusion The combination of sodium hyaluronate injection and celecoxib for the treatment of knee osteoarthritis can enhance the alleviation of patients'joint inflammatory re-sponse and pain,and the condition control effect is good,which is conducive to the improvement of patients'knee joint function and the enhancement of their quality of life level.
万方数据
维普
