Study on the Effect of Dapagliflozin Combined with Trimetazidine on Left Ventricular Ejection Fraction and 6-Minute Walking Distance in Patients with Coronary Heart Disease Combined with Chronic Heart Failure
Objective To investigate the clinical effect of dapagliflozin combined with trimetazidine in the treatment of coronary atherosclerotic heart disease complicated with chronic heart failure(CHF).Methods 80 patients with coro-nary heart disease combined with chronic heart failure(CHF)who were discharged from the Department of Cardiology of the Third Affiliated Hospital of Qiqihar Medical College and followed up from June 2022 to January 2023 were se-lected and divided into the control group and the study group according to the randomized control method,with 40 pa-tients in each group.The patients in the control group were treated with oral dapagliflozin for chronic heart failure,and the patients in the study group were treated with oral dapagliflozin combined with trimetazidine for chronic heart failure.Patients in the two groups were treated with continuous medication for 6 months,and the therapeutic effect of the two groups was compared.Results After treatment,the total effective rate of the study group was 95%higher than that of the control group(67.5%),the difference was statistically significant(χ2=9.921,P<0.05).After treatment,ejec-tion fraction,cardiac output and stroke volume were significantly increased,and left ventricular end-diastolic inner di-ameter was significantly decreased in study groups,and were better than those in the control group,the differences were statistically significant(all P<0.05).The 6 min walking distance was significantly higher in the study group than in the control group after treatment,and the difference was statistically significant(P<0.05).Conclusion Dapagliflozin combined with trimetazidine provides a new drug combination therapy for patients with coronary heart disease and chronic heart failure,which is very effective in improving the patients'exercise capacity and improving the quality of life,and enhances the cure rate of the patients.
万方数据
维普
