Effects of Tacrolimus Combined with Cyclophosphamide on Inflammation and Immune Indexes in Patients with Systemic Lupus Erythematosus
Objective To study and analysis the effects of tacrolimus combined with cyclophosphamide on inflamma-tion and immune indexes in patients with systemic lupus erythematosus.Methods 60 patients with systemic lupus ery-thematosus admitted to Xianyou County General Hospital from February 2021 to September 2023 were randomly se-lected as the study objects and divided into two groups with 30 cases in each group by random number table method.The control group received cyclophosphamide alone,and the observation group received tacrolimus and cyclophospha-mide.The efficacy,inflammatory indexes,immune indexes and safety of the two groups were compared.Results The total effective rate of observation group was 93.33%,which was higher than that of control group(73.33%),and the dif-ference was statistically significant(χ2=4.320,P=0.037).After treatment,The levels of various indicators of inflamma-tion[Interleukin-6(IL-6),Interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α)]in the observation group were lower than those of control group,and the differences were statistically significant(all P<0.05).All immune indexes[Immunoglobulin A,G,M(IgA,IgG,IgM)]in observation group were lower than those in control group,and the differ-ences were statistically significant(all P<0.05).The incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion Tacrolimus combined with cyclophosphamide can improve the therapeutic effect of systemic lupus erythematosus patients,can more effec-tively reduce inflammation,regulate the immune status of the body,and reduce the occurrence of adverse reactions.
Systemic lupus erythematosusTacrolimusCyclophosphamideBody inflammationImmune status
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维普
