Objective To explore the effect of laparoscopic minimally invasive surgery on improving intestinal micro-ecology and serum tumor marker levels in patients with colon cancer.Methods A total of 100 patients admitted to De-partment of Gastrointestinal Surgery of Huai'an First Hospital Affiliated to Nanjing Medical University from August 2020 to August 2023 were randomly selected as the study objects.The patients were divided into study group and ref-erence group by Excel table method,with fifty cases in each group.The reference group underwent open surgery,and the study group underwent minimally invasive laparoscopic surgery.The surgical indexes,intestinal microecology,se-rum tumor markers and postoperative complications were compared between the two groups.Results The intraoperative blood loss,feeding time,exhaust time and hospital stay in the study group were lower than those in the reference group,and the differences were statistically significant(all P＜0.05).The levels of lactobacillus and bifidobacterium in study group were higher than those in reference group,and the differences were statistically significant(both P＜0.05).The levels of Escherichia coli,Clostridium tenuis,Bacteroides and clostridium in study group were lower than those in reference group.The levels of solubleinterleukin-2receptor,colon cancer specific antigen-2,pleiotrophin and mid-kine in the study group were lower than those in the reference group,and the differences were statistically significant(all P＜0.05).The incidence of postoperative complications in the study group(4.00%)was lower than that in the refer-ence group(18.00%),and the difference was statistically significant(χ2=5.005,P＜0.05).Conclusion Compared with open surgery,laparoscopic minimally invasive surgery in the treatment of colon cancer patients can improve the thera-peutic effect,improve surgical indicators,intestinal microbes and serum tumor markers,and reduce postoperative com-plications.
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