Effects of Sacubactril Valsartan Combined with Adenosine Meglumine Cy-clophosphor on Heart Rate Variability and Cardiac Function in Elderly Patients with Chronic Heart Failure
Objective To investigate the effects of sacubactril valsartan combined with adenosine meglumine cyclo-phosphor on heart rate variability and cardiac function in elderly patients with Chronic Heart Failure(CHF).Methods 68 elderly patients with CHF treated in Nayong County People's Hospital of Guizhou Province from March 2021 to May 2023 were conveniently selected as the study objects and were divided into two groups according to simple ran-dom sampling method.The control group(n=34)was treated with adenosine meglumine cyclophosphor,and the obser-vation group(n=34)was treated with sacubactril valsartan.The heart rate variability,cardiac function indexes and ad-verse reactions were compared between the two groups.Results After treatment,the mean standard deviation of RR in-terval in observation group[(80.95±8.14)ms],the standard deviation of RR interval in all sinus beats[(86.51±6.44)ms],and the percentage of difference between adjacent NN＞50 ms in total sinus beats[(12.41±1.19)%]were higher than those in control group.The differences were statistically significant(t=3.947,2.894,8.281,all P＜0.05).The left ventricular end-systolic volume[(141.21±14.99)mL]and the left ventricular end-diastolic volume[(214.88±19.73)mL]in the observation group were lower than those in the control group,and the left ventricular ejection fraction[(43.02±4.05)%]was higher than that in the control group,the differences were statistically significance(t=3.419,2.040,6.623,all P＜0.05);There was no statistically significant difference in the incidence of adverse reactions be-tween the two groups(P＞0.05).Conclusion In elderly patients with CHF,the combination of sacubactril valsartan and adenosine meglumine cyclophosphor has a significant effect,which can improve cardiac function indicators and con-trol heart rate variability,and the drug is safe.
Chronic heart failureElderlySacubatrol valsartanAdenosine meglumine cyclophosphorHeart rate variabilityCardiac function
万方数据
维普
