Clinical Effect of Different Doses of Levothyroxine in the Treatment of Pregnancy Complicated with Hypothyroidism
Objective To observe and analyze the clinical effect of different doses of levothyroxine(L-T4)in the treat-ment of pregnancy complicated with hypothyroidism.Methods A total of seventy-four pregnant patients with hypothy-roidism who received levothyroxine treatment in Ningde Maternal and Child Health Hospital from March 2021 to Feb-ruary 2023 were conveniently selected as the study objects.Patients were divided into low-dose group and high-dose group(37 cases each)according to the order of treatment.The low-dose group was treated with low-dose L-T4(initial dose 25 μg/time),and the high-dose group was treated with high-dose L-T4(initial dose 50 μg/time).Thyroid Stimu-lating Hormone(TSH),Triiodothyronine(T3),Tetraiodothyronin(T4),Free Triiodothyronine(FT3),Free Tetraiodothyro-nin(FT4)and pregnancy outcomes were compared between the two groups.Results After L-T4 treatment,compared with the low-dose group,the TSH level in the high-dose group was significantly decreased,and FT3,FT4,T3 and T4 were increased,and the differences were statistically significant(all P＜0.05).The preterm birth rate of the high-dose group was 5.41%,which was lower than that of the low-dose group(27.03%),and the differences were statistically sig-nificant(χ2=4.874,P＜0.05).The incidence rates of postpartum hemorrhage and neonatal asphyxia were compared be-tween groups,and the differences were not statistically significant(both P＞0.05).Conclusion Compared with pregnant patients with hypothyroidism treated with low-dose L-T4,higher dose is more helpful to regulate the level of thyroid hormone in pregnant women and improve the pregnancy outcome,which is conducive to maternal and infant health.
Pregnancy complicated with hypothyroidismLevothyroxineHigh-doseClinical effect
万方数据
维普
