Study on the Effect Norepinephrine in Patients with Severe Septic Shock
Objective To analyze the effect of norepinephrine in patients with severe septic shock.Methods 60 pa-tients with severe septic shock treated in Zhangzhou Second Hospital from January 2021 to July 2023 were randomly selected as the study objects,and randomly divided into control group and observation group by drawing lots,with 30 cases in each group.Control group and observation group were treated with dopamine and norepinephrine respec-tively.The therapeutic effect of the two groups was compared.Results After treatment,the heart rate of the observation group was lower than that of the control group,and the measured values of mean arterial pressure and central venous pressure of the observation group were higher than those of the control group,C-reactive protein,white blood cell count,neutrophil count,serum procalcitonin,blood urea nitrogen and blood creatinine were lower than those of control group,and the differences were statistically significant(all P＜0.05).At 6 h,24 h and 48 h after treatment,the lactic acid clearance rate of observation group were higher than those of control group,and the differences were statistically significant(all P＜0.05).The total effective rate of the observation group(96.67%)was higher than that of the control group(76.67%),and the difference was statistically significant(χ2=5.192,P＜0.05).There was no statistically signifi-cant difference in the incidence of adverse reactions between the two groups(6.67%vs 16.67%)(χ2=1.456,P＞0.05).Conclusion The application of norepinephrine in the treatment of patients with severe septic shock can stabilize their hemodynamics,reduce inflammatory response and improve renal function,contribute to the clearance of lactic acid and improve the therapeutic effect.
万方数据
维普
