Effect of Sodium Bicarbonate Combined with Acetylcysteine on Reducing Contrast Nephropathy on the Basis of Full Hydration
Objective To evaluate the effect of sodium bicarbonate(SB)combined with N-acetylcysteine(NAC)on re-ducing contrast-induced nephropathy(CIN)in patients with coronary heart disease(CHD)with chronic kidney disease(CKD)on the basis of adequate hydration.Methods A total of one hundred and twenty patients with CKD who under-went percutaneous coronary interventions(PCI)in Guangxi Zhuang Autonomous Region Ethnic Hospital from August 2020 to July 2022 were randomly selected as the research objects.They were divided into conventional treatment group(NS group),sodium bicarbonate(SB group),acetylcysteine group(NAC group)and sodium bicarbonate com-bined acetylcysteine group(SB+NAC group)by random number table method,with thirty cases in each group.NS group was given continuous hydration treatment before PCI;SB group was given SB on the basis of NS group;In NAC group,N-acetylcysteine effervescent tablets were taken orally before and after surgery on the basis of NS group;SB+NAC group was treated with NAC group on the basis of SB group.Serum indexes of serum creatinine(SCr)and cys-tatin C(Cys-C)in 4 groups were analyzed before surgery and 48 h after PCI.Calculated creatinine clearance(Ccr)and estimated glomerular filtration rate(eGFR)were calculated and recorded.Results There were statistically signifi-cant differences in eGFR,Ccr,SCr and Cys-C in NS group,SB group,NAC group and SB+NAC group(all P<0.05).The number of CIN cases in NS group,SB group,NAC group and SB+NAC group were 7,5,3 and 0,there was statisti-cally significant differences in CIN in the 4 groups(χ2=8.152,P<0.05).Conclusion Based on hydration,sodium bicar-bonate,N-acetylcysteine and their combination can effectively reduce the occurrence of CIN after PCI in CKD pa-tients,and the combination of the two drugs is better than the single application.
NETL
NSTL
万方数据
维普
