A Comparative Study of Leuprorelin Acetate Microspheres and Dienogest Tablets Treatment in Patients with Endometriotic Cysts after Surgery
Objective To explore the clinical value of the application of leuprorelin acetate microspheres versus dieno-gest tablets after surgical treatment of patients with endometriotic cysts(Endometrioma,EMA).Methods The clinical data of 70 patients with EMA treated in Yubei District Maternal and Child Health Hospital of Chongqing from June 2021 to June 2022 were retrospectively selected.All cases were treated with surgery,and were divided into group A(leuprelin acetate microspheres,n=35)and group B(dinorgestrel tablets,n=35)according to postoperative medication.The therapeutic effect,ultrasound reexamination results,changes in ovarian function and incidence of adverse events were compared between the two groups.Results The total effective rate was 97.14%in group A and 91.43%in group B,and there was no statistically significant difference between the two groups(χ2=1.061,P=0.303).The incidence of adverse events was 25.71%in group A,which was higher than 5.71%in group B,and the difference was statistically significant(χ2=5.285,P=0.022).After treatment,there was no statistically significant difference in uterine volume and endometrial thickness between the two groups(both P>0.05).After treatment,the number of sinusoidal follicles in group A and the level of anti-Mullerian hormone index in early follicle stage were higher than those in group B,and the differences were statistically significant(all P<0.05).Conclusion Both leuprelin and dinorgestrel have good effects in the postoperative adjuvant treatment of EMA,which can effectively reduce the risk of recurrence.However,the for-mer has a higher risk of adverse events,and the ovarian reserve function is greatly affected during the course of admin-istration.Therefore,dinorgestrel adjuvant therapy can be given priority in women of childbearing age.
Endometriotic cystsDienogestLeuprorelinDisease recurrenceOvarian reserve function
NETL
NSTL
万方数据
维普
