Evaluation of the Effectiveness of Combined Periodontal Basal Therapy with Minocycline Hydrochloride in Patients with Chronic Periodontitis
Objective To analyze the effect of combined treatment of minocycline hydrochloride and periodontal basal therapy on the clinical efficacy of patients with chronic periodontitis.Methods A total of 94 patients with chronic peri-odontitis who received treatment in Weihai Maternal and Child Health Hospital of Shandong Province from January 2022 to April 2023 were conveniently selected as the study objects,and they were divided into control group(47 cases)and observation group(47 cases)according to random drawing method.The control group received periodontal basic treatment,and the observation group received minocycline hydrochloride combined with periodontal basic treat-ment.The therapeutic effect of the two groups was compared.Results The recurrence rate of the observation group was 2.13%,lower than that of the control group(17.02%),and the total clinical efficacy was 95.74%,higher than that of the control group(80.85%),and the differences were statistically significant(χ2=4.423,5.044,both P<0.05).After treatment,the levels of matrix metalloproteinase,interleukin-8,interleukin-6 and tumor necrosis factor-α in observa-tion group were lower than those in control group,and the differences were statistically significant(all P<0.05).After treatment,the periodontal pocket probing depth,periodontal attachment level and gingival sulcus bleeding index in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion Chronic periodontitis patients can improve the clinical efficacy and reduce the recurrence rate by receiving minocycline hydrochloride combined with periodontal basal therapy,which plays an important role in re-ducing inflammatory factors and improving periodontal health.
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维普
