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小儿病毒性脑炎继发癫痫的危险因素分析

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目的 探讨小儿病毒性脑炎(Viral Encephalitis,VE)继发癫痫(Epilepsy,EP)的危险因素.方法 方便选取2022年1月—2023年7月滨州市中心医院收治的98例VE患儿为研究对象,统计EP发生情况,并进行单因素分析与多因素Logistic回归分析以明确VE继发EP的危险因素.结果 98例VE患儿中,26例(26.53%)继发EP;EP组家族EP史、痫性发作次数>2次、未使用抗癫痫药物比例较非EP组更高,差异有统计学意义(P均<0.05);多因素Logistic回归分析结果显示,家族EP史(OR=2.369)、痫性发作次数(OR=3.415)是小儿VE继发EP的独立危险因素(P均<0.05),使用抗癫痫药物(OR=0.127)是小儿VE继发EP的保护因素(P<0.05).结论 小儿VE继发EP的危险因素主要包括家族EP史、痫性发作次数等,使用抗癫痫药物可降低继发EP的发生率.
Analysis of Risk Factors of Epilepsy Secondary to Viral Encephalitis in Children
Objective To investigate the risk factors of epilepsy(EP)secondary to viral encephalitis(VE)in children.Methods A total of ninety eight cases of VE children admitted to Binzhou Central Hospital from January 2022 to July 2023 were conveniently selected as the study objects to analyze the incidence of EP.Univariate analysis and multivari-ate Logistic regression analysis were performed to identify the risk factors of VE secondary EP.Results Of 98 children with VE,26(26.53%)had secondary EP.The family history of EP,the number of epileptic seizures>2 times and the proportion of no use of antiepileptic drugs in EP group were higher than those in non-EP group,the difference was sta-tistically significant(all P<0.05).Multivariate Logistic regression analysis showed that family EP history(OR=2.369)and the number of epileptic seizures(OR=3.415)were independent risk factors for secondary EP in children with VE(all P<0.05).The use of antiepileptic drugs(OR=0.127)was a protective factor for secondary EP in children with VE(P<0.05).Conclusion The risk factors of secondary EP in children with VE mainly include family EP history,the num-ber of epileptic seizures>2 times.The use of antiepileptic drugs can reduce the incidence of secondary EP.

Pediatric viral encephalitisEpilepsyRisk factor

王冬玲、王胜男、张乐

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滨州市中心医院特检科,山东滨州 251700

小儿病毒性脑炎 癫痫 危险因素

2024

中外医疗
卫生部医院管理研究所 二十一世纪联合创新医药科学研究院

中外医疗

影响因子:0.909
ISSN:1674-0742
年,卷(期):2024.43(5)
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