Analysis of the Effect of Entecavir Combined with Reduced Glutathione in the Treatment of Hepatitis B Cirrhosis
Objective To explore the effect of entecavir combined with reduced glutathione in the treatment of hepati-tis B cirrhosis.Methods A total of 106 patients with hepatitis B cirrhosis admitted to the Affiliated Hospital of Qing-dao University from February to December 2023 were conveniently selected as the study objects.According to the ad-mission order of the patients,they were divided into observation group and control group,with 53 cases in each group.The control group was treated with Entecavir,the observation group was treated with reduced glutathione on the basis of the control group,and the therapeutic effect of the two groups was compared.Results The total effective rate of the observation group was 98.11%,which was higher than that of the control group(84.91%),and the difference was statis-tically significant(χ2=4.371,P<0.05).Before treatment,There was no statistically significant difference in the levels of Alanine Transaminase(ALT),Aspartate Transaminase(AST)and Total Bilirubin(TBil)in the two groups(all P>0.05).After treatment,the level of ALT,AST and TBil in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).Before treatment,there was no statistically significant dif-ference in CD4+/CD8+,CD4+ and CD8+ levels between the two groups(all P>0.05).After treatment,the levels of CD4+/CD8+ and CD4+ in observation group were higher than those in control group,and CD8+ was lower than those in con-trol group,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the ob-servation group was 1.00%,lower than that in the control group(8.00%),and the difference was statistically signifi-cant(P<0.05).Conclusion The effect of entecavir combined with reduced glutathione in the treatment of hepatitis B cirrhosis is more obvious,which can improve the liver function of patients,improve the immune function of patients,and have fewer adverse reactions.
Reduced glutathioneEntecavirHepatitis B cirrhosisLiver fibrosis
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NSTL
万方数据
维普
