氨茶碱与多索茶碱应用在慢阻肺临床治疗的效果及药学分析
Clinical Effect and Pharmaceutical Analysis of Aminophylline and Doxofyl-line in the Treatment of COPD
巴莹 1黄静 1李琳1
作者信息
- 1. 峄城区人民医院药剂科,山东枣庄 277300
- 折叠
摘要
目的 讨论氨茶碱与多索茶碱应用在慢性阻塞性肺疾病(简称慢阻肺)临床治疗中的效果及药学分析.方法 随机选取2022年6月—2023年9月峄城区人民医院收治的100例慢阻肺患者为研究对象,应用随机数表法分为对照组与研究组,各50例.对照组予以氨茶碱治疗,研究组予以多索茶碱治疗.比较两组治疗效果、不良反应、气道重塑指标、肺功能指标.结果 研究组总有效率(96.00%)较对照组(84.00%)更高,差异有统计学意义(χ2=4.000,P<0.05).研究组不良反应发生情况与对照组十分相近,差异无统计学意义(P>0.05).治疗7 d后,与对照组比较,研究组肺功能指标均明显上升,而气道重塑指标均明显降低,差异有统计学意义(P均<0.05).结论 氨茶碱与多索茶碱应用在慢阻肺临床治疗中安全性相当,但后者治疗效果更高,更利于防范气道重塑,促使肺功能恢复.
Abstract
Objective To discuss the clinical effect and pharmaceutical analysis of aminophylline and doxofylline in the treatment of chronic obstructive pulmonary disease(COPD).Methods A total of 100 COPD patients in Yicheng District People's Hospital from June 2022 to September 2023 were randomly selected as the study objects and were di-vided into the control group and the research group by random number table method,with 50 cases in each group.The control group was treated with aminophylline and the study group was treated with doxofylline.The therapeutic effect,adverse reactions,airway remodeling indexes and lung function indexes were compared between the two groups.Re-sults The total effective rate of the study group(96.00%)was higher than that of the control group(84.00%),and the difference was statistically significant(χ2=4.000,P<0.05).The incidence of adverse reaction in the study group was similar to those in the control group,the difference was not statistically significant(P>0.05).After 7 days of treatment,compared with the control group,the pulmonary function indexes of the study group were significantly increased,while the airway remodeling indexes were significantly decreased,and the difference was statistically significant(all P<0.05).Conclusion Aminophylline and doxofylline have similar safety in the clinical treatment of COPD,but the latter has a higher therapeutic effect,which is more conducive to preventing airway remodeling and promoting lung function recovery.
关键词
慢阻肺/氨茶碱/多索茶碱Key words
COPD/Aminophylline/Doxofylline引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据