Efficacy and Safety Analysis of Diphereline Combined with Levonorgestrel Sustained Release System in the Treatment of Patients with Uterine Adeno-myosis
Objective To explore the efficacy and safety of Dafiline combined with levonorgestrel sustained release system in the treatment of patients with uterine adenomyosis.Methods A total of 102 patients with adenomyosis admit-ted to Nanjing Jiangning Hospital of Traditional Chinese Medicine from June 2019 to December 2022 were conve-niently selected as the study objects.All patients were numbered after admission,and randomly divided into control group and observation group with 51 cases in each group using the red and blue ball method.The control group was treated with levonorgestrel sustained release system,and the observation group was treated with Dafilin on the basis of the control group.After treatment,the clinical efficacy,serum factor levels and safety of the two groups were compared.Results The total effective rate of the observation group was 96.08%,higher than that of the control group(84.31%),and the difference was statistically significant(χ2=3.991,P<0.05).After treatment,there was no significant difference in the level of human epididymis protein 4 between the two groups(P>0.05).The levels of Cancer Antigen 199(38.21±4.12)U/mL and cancer antigen 125(16.57±3.71)U/mL in observation group were lower than those in control group,and the difference was statistically significant(t=7.119,5.350,both P<0.05).The total incidence of adverse events in the observation group(3.92%)was lower than that in the control group(17.65%),and the difference was statistically significant(χ2=4.993,P<0.05).Conclusion For patients with adenomyosis,the combination of Tamiline and levonorg-estrel sustained release system can help to further improve the clinical therapeutic effect and reduce the level of ad-enomyosis related factors,with high safety.
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NSTL
万方数据
维普
