Curative Effect of Nimodipine Combined with Alprostadil in the Treat-ment of Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage
Objective To analyze the clinical effect of nimodipine combined with alprostadil in the treatment of cere-bral vasospasm(CVS)in aneurysms subarachnoid hemorrhage(aSAH).Methods 76 patients with aSAH CVS admitted to Feng County Traditional Chinese Medicine Hospital from January 2020 to June 2023 were conveniently selected as the research subjects and randomly divided into two groups using a random number table.The control group(38 cases)received treatment with nimodipine,while the observation group(38 cases)received treatment with nimodipine com-bined with alprostadil.The mean intracranial blood flow velocity,serological indexes,coma state,cognitive function scores and the incidence of adverse reactions were compared between the two groups.Results After treatment,the av-erage blood flow velocity of the anterior,posterior,and middle arteries in the observation group was lower than that in the control group,and the differences were statistically significant(all P<0.05).The levels of interleukin-6,vascular endothelial growth factor,hypersensitive C-reactive protein,and endothelin-1 in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The scores of Glasgow Coma Scale and Montreal Cognitive Assessment of the observation group were(12.41±2.23)points and(26.02±1.97)points,respectively,higher than the control group's(10.33±2.15)points and(21.26±2.15)points,and the differences were statistically significant(t=4.139 and 10.062,both P<0.05).The total incidence of adverse reactions in the obser-vation group and the control group were 13.16%and 10.53%respectively,and the difference was not statistically sig-nificant(P>0.05).Conclusion In aSAH CVS patients,nimodipine combined with alprostadil can improve intracranial blood flow velocity,improve coma state and cognitive function,protect vascular endothelial function,reduce inflamma-tion,and do not increase adverse reactions.
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万方数据
维普
