Effect of Antagonist Regimen Combined with Growth Hormone Injection on Pregnancy Outcome in Patients with Ovarian Hyporesponsiveness
Objective To investigate the effect of antagonist regimen combined with growth hormone(GH)injection on pregnancy outcome in patients with ovarian hyporesponsiveness(POR).Methods Clinical data of Eighty patients with POR who underwent in vitro fertilization-embryo transfer(IVF-ET)treatment with antagonist regimen from March 2020 to July 2023 in Xuzhou Maternal and Child Health Hospital were retrospectively selected.They were grouped ac-cording to whether GH was applied or not,those treated with combined GH injection were included in the observation group,and those treated with single antagonist regimen were included in the control group,with 40 cases in both groups.The pregnancy situation of the two groups was compared,including the number of eggs obtained,the rate of transferable embryos on the 3rd day,the rate of blastocyst formation,the clinical pregnancy rate,the implantation rate,the rate of MⅡ eggs,the rate of normal fertilization,the rate of high-quality embryos on the 3rd day and the rate of high-quality blastocysts.Results After treatment,there was no significant difference in MⅡ egg rate,normal fertiliza-tion rate,good quality embryo rate and good quality blastocyst rate between the two groups(all P>0.05).The number of eggs collected in observation group(10.78±4.02)was higher than that in control group(7.36±2.15),and the differ-ence was statistically significant(t=4.745,P<0.05).The transplantable embryo rate on the 3rd day,blastocyst forma-tion rate,clinical pregnancy rate and implantation rate in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion The antagonist regimen combined with GH injection can improve the pregnancy outcome of POR patients and increase the fertility success rate of the pa-tients.
In vitro fertilization-embryo transferInfertilityAntagonist regimenGrowth hormoneOvarian hyporesponsivenessPregnancy outcome
NETL
NSTL
万方数据
维普
