Efficacy and Safety Analysis of Meropenem in the Treatment of Severe Pneumonia in Elderly People
Objective To study the effectiveness and safety of meropenem in the treatment of severe pneumonia in the elderly.Methods 80 elderly patients with severe pneumonia admitted to Jinan Combined Hospital of Traditional Chi-nese and Western Medicine from April 2021 to April 2022 were selected randomly as the study subjects.They were divided into a study group and a reference group using random number table method,with 40 cases in each group.The reference group was treated with Xuebijing combined with non-invasive mechanical ventilation,while the study group was treated with meropenem on the basis of the reference group.The clinical efficacy,lung function indexes,total inci-dence of adverse reactions,the leves of serum C-reactive Protein(CRP)and Procalcitonin(PCT),as well as the score of Standardized Swallowing Assessment(SSA)were compared between the two groups.Results The total effective rate of treatment in the study group(92.50%)was higher than that in the control group(70.00%),and the difference was statistically significant(χ2=6.646,P=0.010).There was no statistically significant difference in lung function indexes between the two groups before treatment(P>0.05).After treatment,the lung function index in the study group was bet-ter than that in the control group,and the difference was statistically significant(P<0.05).The total incidence of ad-verse reactions in the study group was 10.00%,lower than the reference group's 37.50%,and the difference was statis-tically significant(P<0.05).There were no statistically significant differences in levels of serum CRP and PCT,and SSA scores between the two groups before treatment(all P>0.05).After treatment,the serum CRP and PCT levels,and SSA scores in the study group were lower than those in the control group,and the differences were statistically signifi-cant(all P<0.05).Conclusion Elderly patients with severe pneumonia carry out meropenem treatment,can improve the clinical symptoms of the patients,recovery pulmonary function,and have fewer adverse reactions,reduce serum CRP and PCT level,and swallowing ability improvement is significant.
MeropenemElderly severe pneumoniaEffectivenessSafety
NETL
NSTL
万方数据
维普
