Effect of Budesonide Combined with Azithromycin Sequential Therapy on Serum Inflammatory Factors in Children with Mycoplasma Pneumonia
Objective To investigate the effect of budesonide combined with azithromycin sequential therapy on serum inflammatory factors in children with mycoplasma pneumonia(MPP).Methods 120 cases of children with MPP admit-ted to Qianxinan Prefecture Maternal and Child Health Hospital from January 2022 to December 2022 were selected conveniently as the study objects and divided into two groups according to the randomized numerical table method.On the basis of conventional treatment,azithromycin sequential therapy was used in the control group(60 cases),and budesonide combined with azithromycin sequential therapy was used in the observation group(60 cases).The two groups were compared in terms of total effective rate of treatment,time to disappearance of clinical symptoms,dyspnea index,serum inflammatory factor level and the occurence of adverse reactions.Results The total effective rate of the observation group was 93.33%,significantly higher than that of the control group,which was 71.67%,and the differ-ence was statistically significant(χ2=9.755,P=0.002).The time for fever reduction,cough suppression and disappear-ance of rales in the observation group was shorter than that in the control group,and the differences were statistically significant(t=13.669,15.581,2.769,all P<0.05).The dyspnea index of the observation group was significantly lower than that of the control group after treatment,the difference was statistically significant(Z=3.449,P<0.05),and the av-erage of C-reactive protein and procalcitonin was lower than that of the control group,the differences were statistically significant(t=2.465,15.423,all P<0.05),and there was no statistically significant difference in the comparison of ad-verse reactions between two groups(χ2=0,P=1.000).Conclusion Budesonide combined with azithromycin sequential therapy can effectively improve the level of inflammatory factors,dyspnea index,accelerate the disappearance of clini-cal symptoms in children with MMP,with high safety.
NETL
NSTL
万方数据
维普
