Therapeutic Effect of Ambroxol Hydrochloride Intravenous Infusion Com-bined with Oral Azithromycin in Patients with Bronchial Pneumonia
Objective To analyze the therapeutic effect of oral azithromycin and intravenous infusion of ambroxol hy-drochloride on bronchial pneumonia.Methods A total of 150 children treated with bronchopneumonia in the pediat-rics department of Taiwan Investment Area Hospital in Quanzhou,Fujian Province from July 2020 to July 2023 were conveniently selected as the study objects,and they were divided into control group and study group by random num-ber method,with 75 cases in each group.The control group was given oral azithromycin,and the study group was given intravenous infusion of ambroxol hydrochloride + oral azithromycin.The duration of symptom resolution,inci-dence of adverse reactions,levels of inflammatory factors and changes in arterial blood gas before and after treatment were compared between the two groups.Results The duration of cough,fever,lung rales,dyspnea and other symptoms were(3.03±0.85),(2.82±0.65),(2.12±0.56),(2.05±0.44)d,respectively.which shorter than that of control group(5.41±1.16)d,(5.23±1.02),(4.63±1.35),(4.16±1.12)d,and the differences were statistically significant(t=14.332,17.256,14.873,15.185,all P<0.001).There was no significant difference in the incidence of adverse reactions between the study group(9.33%)and the control group(6.67%)(χ2=0.362,P=0.547).Before treatment,there was no significant dif-ference in blood oxygen saturation,tumor necrosis factor-α,pH value,interleukin-6,partial pressure of carbon diox-ide,C-reactive protein and partial pressure of oxygen between the two groups(all P>0.05).After treatment,tumor ne-crosis factor-α,interleukin-6,C-reactive protein and partial pressure of carbon dioxide in the study group were lower than those in the control group,while the other three arterial blood gas indexes were higher than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion Oral azithromycin + intravenous infu-sion of ambroxol hydrochloride in the treatment of bronchial pneumonia can not only improve the clinical symptoms and arterial blood gas status of children,but also reduce the inflammatory response,and the safety is very high.
NETL
NSTL
万方数据
维普
